Design, Synthesis and Evaluation of Phthalimide and Its Derivatives

Abstract

The synthesis, structural characterisation, and antimicrobial assessment of phthalimide and its major derivatives potassium phthalimide, N-benzyl phthalimide, N-phenyl phthalimide, and N-anthraniloyl phthalimide are the main objectives of this study. Under carefully monitored circumstances, nucleophilic substitution and condensation reactions were used to create these derivatives. Thin Layer Chromatography (TLC), melting point determination, and spectroscopic methods including infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy were used to characterise the compounds and verify their structures and purity. Disc diffusion and minimum inhibitory concentration (MIC) techniques were used to evaluate antimicrobial activity against specific bacterial strains. N-benzyl and N-anthraniloyl phthalimide showed encouraging antibacterial activity, suggesting that they could be used as lead molecules in the creation of novel therapeutic agents.

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